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KMID : 0861020080230020213
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Korea Journal of Herbology
2008 Volume.23 No. 2 p.213 ~ p.223
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Hypotensive Effect of Scrophularia buergeriana and Gene Analysis of Scrophularia Species
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Park Kyu-Ha
Ham In-Hye
Choi Ho-Young
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Abstract
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Objectivies: This study was performed to prove the hypotensive effect of 70% MeOH extracts from Scrophularia buergeriana (SB) on rat’s femoral artery.
Methods: We observed hypotensive effect of SB on rat’s femoral artery. Scrophularia buergeriana Miquel., S. kakudensis, S. koraiensis and S. ningpoenesis Hemsl. were used by the RFLP method and sequence analysis of ITS regions, in order to compare and discriminate.
Results: SB 70% MeOH Ex., Water fraction, 40% MeOH fraction, 100% MeOH fraction didn’t show significantly hypotensive effect. 20% fraction of SB 70% MeOH Ex. showed significantly hypotensive effect. The size of ITS region on Scrophularia sp. is 589～590bp and amount of G+C is 59.3% to 59.7%, and it showed the similar of ITS parts on Scrophularia sp.
Conclusions: We concluded that SB Ex. have hypotensive activity, and it’s more efficient when separated. And Scrophularia sp. showed the similar of DNA analysis.
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KEYWORD
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Scrophularia buergeriana, hypotensive effect, DNA analysis
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